Endocrine Abstracts

In this talk, I will discuss the integrated role of hypothalamic inflammation and GnRH dysfunction in the development of systemic aging. First, I will provide an overview on aging-related profiles of hypothalamic pro-inflammatory NF-kB pathway as well as GnRH change. Second, I will describe how these changes can employ a neurodegenerative mechanism, in particular through targeting hypothalamic neural stem cells, to mediate the pathogenesis of aging and many aging-related disor...